How PULMICORT RESPULES Works

PULMICORT RESPULES targets an underlying cause of asthma — inflammation.^7,8,9 The precise mechanism of corticosteroid action on inflammation in asthma is not fully understood. Inflammation is an important component in the pathogenesis of asthma.^7,8,9

Inflammatory Signal and Trasduction Molecules NOS*, COX†,PLA‡

Footnotes

*Nitric oxide synthase
^†Cyclooxygenase
^‡Phospholipase A
^§Adhesion molecules play a key role in the trafficking of inflammatory cells to site of inflammation⁸
^aAlthough it has been established that corticosteroids can inhibit arachidonic acid formation in vitro, that effect remains unproven in vivo.

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Indication

PULMICORT RESPULES is indicated for the maintenance treatment of asthma and as prophylactic therapy in children ages 12 months to 8 years.

PULMICORT RESPULES is not a bronchodilator and is NOT indicated for the relief of acute bronchospasm.

Important Safety Information

Inhaled corticosteroids may cause a reduction in growth velocity. The long-term effect on final adult height is unknown.

PULMICORT RESPULES, like other inhaled corticosteroids, may impact the hypothalamic-pituitary-adrenal axis, especially in susceptible individuals, in young children, and in patients given high doses for prolonged periods.

Particular care is needed for patients who are transferred from systemically active corticosteroids to less systemically available corticosteroids, because deaths due to adrenal insufficiency have occurred in asthmatic patients during and after transfer from systemic corticosteroids (see WARNINGS in full Prescribing Information).

Patients taking immunosuppressant doses of corticosteroids should avoid exposure to infections such as chicken pox and measles.

Common adverse events reported in clinical trials, regardless of relationship to treatment, included respiratory infection, rhinitis, coughing, otitis media, viral infection, gastroenteritis, ear infection, oral thrush/candidiasis, and epistaxis.

Please see accompanying full Prescribing Information (PDF).

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